A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
Blog Article
‘The 2nd is nanopores, which happens to be our oldest line of investigation and that has now led to DNA sequencers dependant on nanopores. We pull unique DNA strands by way of a nanopore and can then read through from the nucleotide sequence. Incredibly not too long ago, we even managed to browse out only one protein for The 1st time applying This system. But this line of analysis is don't just about developing instruments, and also about authentic biological inquiries.
Our group studies bacterial mobile division and is particularly aiming to constitute a ‘bottom up biology’ in synthetic cells that may autonomously divide. Our main curiosity lies in cell division, chromatin composition, and spatial Command.
, Groningen researchers current the final results of their endeavours to generate labs extra sustainable and provide tips for other labs.
2007, initially actual-time detection of strand Trade in homologous recombination by RecA; discovery of a low persistence duration of ends of microtubules; and settled the mechanism of biosensing with carbon nanotubes
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and initial at any time review of your dynamics DNA supercoils and the invention of supercoil hopping
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes
What distinguishes biology from chemistry ceesdekker is the fact these components collectively make up a dwelling program. The secret of mentioned lifetime, I think, lies inside the interactions, the interplay of All those molecules. The big concern in regards to the origin of lifestyle remains to be unanswered. How did we at any time evolve from easy molecules to the really complex techniques we see now? We have no idea. I need to work on these kinds of huge, open up thoughts.’
2011, first in vitro measurements of transportation throughout only one biomimetic nuclear pore elaborate; development of multiplexed magnetic tweezers for kilo-molecule experiments; and fixed the system of homology recognition in DNA homologous recombination
2003, shown the initial biosensors created out of a carbon nanotube; resolved the composition and system of DNA mend proteins; and discovery of a new strategy for fabricating reliable-condition nanopores for DNA translocation
Bulk-area coupling identifies the mechanistic connection among Min-protein styles in vivo and in vitro
Tests pseudotopological and nontopological designs for SMC-pushed DNA loop extrusion versus roadblock-traversal experiments
Nature Physics many thanks the anonymous reviewers for his or her contribution to your peer assessment of the get the job done.
Such as, we look at the nucleopore complicated, a gateway in between the cell nucleus along with the cytoplasm. This is a very complex method and therefore difficult to study in the cell, so we use biomimetics. We reconstruct holes after which insert person aspects from the nucleopore complicated to study transportation by means of it at The only-molecule amount.’
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij fulfilled enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent layout in 2005. (nl)